Stonins--specialized adaptors for synaptic vesicle recycling and beyond?

Traffic. 2010 Jan;11(1):8-15. doi: 10.1111/j.1600-0854.2009.00971.x.


Stonins are a small family of evolutionarily conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis and perhaps beyond. Whereas little is known about the localization and function of stonin 1, recent work suggests that stonin 2 serves as a linker between the endocytic proteins AP-2 and Eps15 and the calcium-sensing synaptic vesicle (SV) protein synaptotagmin 1. The molecular determinants involved in the recognition of SV cargo by the mu-homology domain of stonin 2 are evolutionarily conserved from worm to man, thereby identifying stonin 2 and its invertebrate homologs uncoordinated (UNC)-41 and stoned B as endocytic adaptors dedicated to the retrieval of surface-stranded SV proteins, most notably synaptotagmin. In this review, we summarize the current state of knowledge about mammalian stonins with a special focus on the role of stonin 2 in SV recycling at presynaptic nerve terminals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Protein Complex mu Subunits / chemistry
  • Adaptor Protein Complex mu Subunits / metabolism
  • Adaptor Protein Complex mu Subunits / physiology*
  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Endocytosis / physiology
  • Humans
  • Models, Biological
  • Models, Molecular
  • Presynaptic Terminals / metabolism
  • Presynaptic Terminals / physiology
  • Protein Structure, Tertiary
  • Protein Transport
  • Structural Homology, Protein
  • Synaptic Vesicles / metabolism
  • Synaptic Vesicles / physiology*
  • Synaptotagmin I / chemistry
  • Synaptotagmin I / metabolism
  • Synaptotagmin I / physiology
  • Vesicular Transport Proteins / chemistry
  • Vesicular Transport Proteins / metabolism
  • Vesicular Transport Proteins / physiology


  • Adaptor Protein Complex mu Subunits
  • Adaptor Proteins, Vesicular Transport
  • STON2 protein, human
  • Synaptotagmin I
  • Vesicular Transport Proteins