The yin-yang of tumor-associated neutrophils

Cancer Cell. 2009 Sep 8;16(3):173-4. doi: 10.1016/j.ccr.2009.08.014.


Cancer-related inflammation is a key component of the tumor microenvironment. A report in this issue of Cancer Cell now indicates that tumor-associated neutrophils in lung cancer can polarize to either "N1" or "N2" phenotype that inhibits or promotes cancer development, respectively.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinoma, Non-Small-Cell Lung / immunology*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Lung Neoplasms / immunology*
  • Lung Neoplasms / pathology
  • Mice
  • Neutrophils / immunology*
  • Neutrophils / pathology
  • Small Cell Lung Carcinoma / immunology*
  • Small Cell Lung Carcinoma / pathology
  • Yin-Yang*