Lymphoma: which chemotherapy protocol and why?

Top Companion Anim Med. 2009 Aug;24(3):157-62. doi: 10.1053/j.tcam.2009.03.003.


Lymphoma is the most common hematologic neoplasm of dogs. Although the order of drug administration and duration of the maintenance portion of the protocol vary considerably, most oncologists agree that a doxorubicin-based (eg, CHOP) combination chemotherapy protocol provides the longest period of disease control and overall survival. The use of a prolonged maintenance phase is no longer recommended, but consolidation therapy may prove to be of benefit. Further, combination of chemotherapy with half- or whole-body radiation therapy or even bone marrow transplant is advocated by some institutions. The goal of this article is to summarize the current literature regarding chemotherapy for dogs with high-grade lymphoma and provide recommendations for therapy in a variety of different scenarios.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Cyclophosphamide / administration & dosage
  • Dog Diseases / drug therapy*
  • Dogs
  • Doxorubicin / administration & dosage
  • Lymphoma / drug therapy
  • Lymphoma / veterinary*
  • Prednisone / administration & dosage
  • Vincristine / administration & dosage


  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • CHOP protocol