Focus on the splicing of secretin GPCRs transmembrane-domain 7

Trends Biochem Sci. 2009 Sep;34(9):443-52. doi: 10.1016/j.tibs.2009.06.002. Epub 2009 Sep 3.

Abstract

The family of G-protein coupled receptors (GPCRs) is one of the largest protein families in the mammalian genome with a fundamental role in cell biology. GPCR activity is finely tuned by various transcriptional, post-transcriptional and post-translational mechanisms. Alternative pre-mRNA splicing is now emerging as a crucial process regulating GPCR biological function. Intriguingly, this mechanism appears to extensively target the Secretin family of GPCRs, especially the exon that encodes a 14 amino acid sequence that forms the distal part of 7th transmembrane helix, and exhibits an unusually high level of sequence conservation among most Secretin GPCRs. Do the "TMD7-short" receptor variants have a role as novel regulators of GPCR signallng and, if so, what are the implications for hormonal actions and physiology?

Publication types

  • Review

MeSH terms

  • Alternative Splicing*
  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Exons
  • Humans
  • Models, Molecular
  • Phylogeny
  • Protein Isoforms
  • Protein Structure, Tertiary
  • RNA Splice Sites
  • Receptors, G-Protein-Coupled / chemistry
  • Receptors, G-Protein-Coupled / genetics*
  • Receptors, G-Protein-Coupled / physiology
  • Receptors, Gastrointestinal Hormone / chemistry
  • Receptors, Gastrointestinal Hormone / genetics*
  • Receptors, Gastrointestinal Hormone / physiology
  • Secretin / physiology
  • Sequence Alignment
  • Signal Transduction

Substances

  • Protein Isoforms
  • RNA Splice Sites
  • Receptors, G-Protein-Coupled
  • Receptors, Gastrointestinal Hormone
  • secretin receptor
  • Secretin