Sox2 roles in neural stem cells

Int J Biochem Cell Biol. 2010 Mar;42(3):421-4. doi: 10.1016/j.biocel.2009.08.018. Epub 2009 Sep 3.


Throughout vertebrate evolution, Sox2 marks the developing nervous system from its earliest developmental stages and, therein, the most undifferentiated precursor cells, including stem cells. Recent gene targeting studies investigated the function of Sox2 in two neuronal systems: the developing eye and brain. These studies uncovered a requirement for Sox2 in the maintenance of neural stem cells, as well as a downstream role in the differentiation of specific neuron sub-types. In both systems, Sox2 action is markedly dose-dependent, and downstream-target gene studies are beginning to reveal the mechanisms of Sox2 function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Humans
  • Neoplastic Stem Cells / metabolism
  • Neurons / cytology*
  • SOXB1 Transcription Factors / metabolism*
  • Stem Cells / cytology
  • Stem Cells / metabolism*


  • SOXB1 Transcription Factors