Growth factors and corneal epithelial wound healing

Brain Res Bull. 2010 Feb 15;81(2-3):229-35. doi: 10.1016/j.brainresbull.2009.08.024. Epub 2009 Sep 4.


In this article, we briefly review recent findings in the effects of growth factors including the EGF family, KGF, HGF, IGF, insulin, and TGF-beta on corneal epithelial wound healing. We discuss the essential role of EGFR in inter-receptor cross-talk in response to wounding in corneal epithelium and bring forward a concept of "alarmins" to the field of wound healing research.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Corneal Diseases* / pathology
  • Corneal Diseases* / physiopathology
  • Corneal Diseases* / therapy
  • Epithelium, Corneal / physiopathology*
  • Humans
  • Intercellular Signaling Peptides and Proteins / classification
  • Intercellular Signaling Peptides and Proteins / physiology*
  • Models, Biological
  • Signal Transduction / physiology
  • Wound Healing / physiology*


  • Intercellular Signaling Peptides and Proteins