Efficacy of oral administration of a heat-killed Lactobacillus gasseri OLL2809 on patients of Japanese cedar pollinosis with high Japanese-cedar pollen-specific IgE

Biosci Biotechnol Biochem. 2009 Sep;73(9):1971-7. doi: 10.1271/bbb.90144. Epub 2009 Sep 7.


A randomized, double-blind, placebo-controlled clinical trial was conducted to determine whether oral administration of heat-killed Lactobacillus gasseri OLL2809 would affect the immune response and reduce the symptoms of Japanese cedar pollinosis (JCP) in subjects with JCP. Following a 1-week pre-observation period, the subjects were randomly divided into two groups and were orally administered a placebo or tablets containing 100 mg of L. gasseri OLL2809 per d for 8 weeks during the pollen season in 2007. The results showed no obvious differences between the groups. Supplementary subgroup analysis revealed that the OLL2809 subgroups with CAP-RAST scores of 4 or 5 exhibited improvement in nasal symptoms scores and serum allergy-related items, including Japanese cedar pollen-specific IgE levels. L. gasseri OLL2809 was found to be effective in reducing symptoms in subjects with a high predisposition to allergies by modulating systemic immune systems.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Cryptomeria / immunology*
  • Double-Blind Method
  • Hot Temperature*
  • Humans
  • Immunoglobulin E / immunology*
  • Lactobacillus*
  • Placebos
  • Pollen / immunology*
  • Rhinitis, Allergic, Seasonal / immunology
  • Rhinitis, Allergic, Seasonal / therapy*


  • Placebos
  • Immunoglobulin E