Novel use of amantadine: to treat hiccups

J Pain Symptom Manage. 2009 Sep;38(3):460-5. doi: 10.1016/j.jpainsymman.2008.10.008.


Persistent hiccups may have a considerable impact on general health through disturbance of diet, sleep, and mood. They can cause exhaustion, malnutrition, dehydration, wound dehiscence, and even death in extreme cases. We report a complex clinical case of intractable hiccups in a patient with cancer of the pancreas and Parkinson's disease and some of the problems encountered when attempting symptom control. We also discuss a potential therapeutic response to a novel agent, amantadine, unlicensed in the treatment of hiccups.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amantadine / therapeutic use*
  • Analgesics, Non-Narcotic / therapeutic use*
  • Antidepressive Agents / therapeutic use
  • Fatal Outcome
  • Hiccup / drug therapy*
  • Humans
  • Male
  • Quality of Life
  • Sertraline / therapeutic use
  • Stroke / complications
  • Whipple Disease / complications


  • Analgesics, Non-Narcotic
  • Antidepressive Agents
  • Amantadine
  • Sertraline