Levels of cyclic 3'-5' -adenosine monophosphate (cAMP) in maintenance cultures of rat hepatocytes in response to insulin and glucagon

Lipids. 1977 Jul;12(7):577-80. doi: 10.1007/BF02533384.

Abstract

Under conditions of short-term stimulation of lipogenesis by insulin in maintenance cultures of hepatocytes from starved rats, basal levels of cyclic 3'-5' -adenosine monophosphate (cAMP) are invariant. Glucagon signals increased levels of cAMP and severely diminishes lipogenesis. Insulin partially counteracts both glucagon effects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cells, Cultured
  • Cyclic AMP / metabolism*
  • Cyclic AMP / pharmacology
  • Fatty Acids / biosynthesis
  • Glucagon / pharmacology*
  • Insulin / pharmacology*
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Rats

Substances

  • Fatty Acids
  • Insulin
  • Glucagon
  • Cyclic AMP