A magnetically triggered composite membrane for on-demand drug delivery

Nano Lett. 2009 Oct;9(10):3651-7. doi: 10.1021/nl9018935.


Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were noncytotoxic, were biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry*
  • Acrylic Resins
  • Dose-Response Relationship, Drug
  • Drug Delivery Systems*
  • Fluorescein / chemistry
  • Gels / chemistry
  • Magnetics*
  • Membranes, Artificial*
  • Metal Nanoparticles*
  • Polymers / chemistry*
  • Temperature


  • Acrylamides
  • Acrylic Resins
  • Gels
  • Membranes, Artificial
  • Polymers
  • poly-N-isopropylacrylamide
  • Fluorescein