Association of sleep apnoea with myocardial infarction in men

Lancet. 1990 Aug 4;336(8710):261-4. doi: 10.1016/0140-6736(90)91799-g.


To examine the hypothesis that sleep apnoea is a risk factor for ischaemic heart disease, overnight polysomnography was performed in 101 unselected male survivors of acute myocardial infarction (MI) aged less than 66 yr and in 53 male subjects of similar age without evidence of ischaemic heart disease. The apnoea index (AI, number of apnoea episodes per hour of sleep) was 6.9 (SEM 1.2) in the MI patients versus 1.4 (0.3) in the control subjects. After adjustment for age, body mass index, hypertension, smoking, and cholesterol level, multiple logistic regression analysis identified the top quartile of AI (greater than 5.3) as an independent predictor of MI patients. The relative risk for myocardial infarction between the highest and lowest quartiles of AI was 23.3 (95% confidence interval 3.9-139.9).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Body Mass Index
  • Electrocardiography
  • Evaluation Studies as Topic
  • Humans
  • Hypertension / complications
  • Male
  • Middle Aged
  • Monitoring, Physiologic
  • Myocardial Infarction / complications*
  • Myocardial Infarction / epidemiology
  • Myocardial Infarction / physiopathology
  • Odds Ratio
  • Oximetry
  • Prevalence
  • Regression Analysis
  • Risk Factors
  • Severity of Illness Index
  • Sleep Apnea Syndromes / complications*
  • Sleep Apnea Syndromes / epidemiology
  • Sleep Apnea Syndromes / physiopathology
  • Smoking / adverse effects