Prolonged dependence of ischemic penumbra on induced hypertension

Neurologist. 2009 Sep;15(5):296-7. doi: 10.1097/NRL.0b013e3181990a9a.


Background: Pharmacological elevation of blood pressure in acute stroke due to large artery occlusion may enhance collateral blood flow and salvage penumbral tissue. The duration of viability of human penumbral tissue under such circumstances is unclear.

Objective: To describe a patient presenting with acute middle cerebral artery occlusion treated with induced hypertension who had prolonged survival of penumbral tissue with subsequent infarct extension after pressor agents were withdrawn.

Conclusions: Enhanced collateral flow by elevation of blood pressure may result in prolonged survival of the ischemic penumbra which remains dependent on persistent use of pressor agents.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Brain / blood supply
  • Brain / pathology
  • Brain / physiopathology
  • Cerebral Angiography
  • Humans
  • Hypertension* / physiopathology
  • Infarction, Middle Cerebral Artery / pathology
  • Infarction, Middle Cerebral Artery / physiopathology
  • Infarction, Middle Cerebral Artery / therapy*
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Tomography, X-Ray Computed