Endoplasmic Reticulum Stress: An Unrecognized Actor in Solid Organ Transplantation

Transplantation. 2009 Sep 15;88(5):605-13. doi: 10.1097/TP.0b013e3181b22cec.

Abstract

Endoplasmic reticulum (ER) stress is an adaptive response to the accumulation of misfolded proteins within the ER, which can trigger cell dedifferentiation and cell suicide. Increasing evidences suggest its implication in mediating allograft injury. Herein, we summarize the mechanisms of ER stress and discuss its implication in allograft injury. Increasing our understanding of the cellular and molecular mechanisms of acute and chronic allograft damages could lead to the development of new biomarkers and to the discovery of new therapeutic strategies to prevent the initiation of graft dysfunction or to promote the tissue regeneration after injury.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcineurin Inhibitors
  • Chronic Disease
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Kidney / pathology
  • Models, Biological
  • Protein Denaturation
  • Protein Folding
  • Regeneration
  • Reperfusion Injury
  • Stress, Physiological
  • Transplantation / methods*
  • Transplantation, Homologous / methods

Substances

  • Calcineurin Inhibitors