Implications of chimaeric non-co-linear transcripts

Nature. 2009 Sep 10;461(7261):206-11. doi: 10.1038/nature08452.


Deep sequencing of 'transcriptomes'--the collection of all RNA transcripts produced at a given time--from worms to humans reveals that some transcripts are composed of sequence segments that are not co-linear, with pieces of sequence coming from distant regions of DNA, even different chromosomes. Some of these 'chimaeric' transcripts are formed by genetic rearrangements, but others arise during post-transcriptional events. The 'trans-splicing' process in lower eukaryotes is well understood, but events in higher eukaryotes are not. The existence of such chimaeric RNAs has far-reaching implications for the potential information content of genomes and the way it is arranged.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Genetic Variation
  • Humans
  • Models, Genetic
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism*
  • Trans-Splicing / genetics*
  • Transcription, Genetic


  • RNA, Messenger