Implication of beta3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress

Behav Brain Res. 2010 Jan 20;206(2):310-2. doi: 10.1016/j.bbr.2009.09.003. Epub 2009 Sep 8.

Abstract

The involvement of the beta3-adrenoceptor in the antidepressant-like effects of the beta3-adrenoceptor-agonist amibegron is addressed in the chronic mild stress, using adrenergic beta3-receptor knockout (Adrb3tm1Lowl) mice. Amibegron (3 mg/kg/day, i.p., 33 days), attenuated the physical alteration due to the application of repeated stress in wild-type littermates, but not in knockout mice. This result suggests that the beta3-adrenoceptor plays a predominant role in mediating antidepressant-like actions of amibegron.

MeSH terms

  • Adrenergic beta-3 Receptor Agonists*
  • Adrenergic beta-Agonists / pharmacology*
  • Animals
  • Antidepressive Agents / pharmacology
  • Behavior, Animal / drug effects
  • Mice
  • Mice, Knockout
  • Receptors, Adrenergic, beta-3 / genetics
  • Stress, Physiological / drug effects*
  • Stress, Physiological / genetics
  • Tetrahydronaphthalenes / pharmacology*

Substances

  • Adrenergic beta-3 Receptor Agonists
  • Adrenergic beta-Agonists
  • Antidepressive Agents
  • Receptors, Adrenergic, beta-3
  • Tetrahydronaphthalenes
  • amibegron