Immunohistochemical studies of Vogt-Koyanagi-Harada disease with sunset sky fundus

Curr Eye Res. 1990;9 Suppl:35-40. doi: 10.3109/02713689008999417.


We studied Vogt-Koyanagi-Harada disease (VKH) with sunset sky fundus using histopathology and immunohistochemical methods. The materials examined were 4 eyes obtained at autopsy on two patients with VKH. The first patient died 32 months after the onset of VKH, and the other 7 years after onset. Histopathology of the eyes showed scattering infiltration of lymphocytes in the thickened choroid with a remarkable disappearance of choroidal melanocytes. T and B lymphocytes were identified by immunohistochemistry, using monoclonal antibodies. Approximately 70% of the lymphocytes were T cells. In the case 1 patient, the ratio of CD4+ to CD8+ T cells was 2 to 3. Thus, the evidence of T and B lymphocytes in these uveal tissues indicates that the inflammation remained active even at the convalescent stage.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal
  • B-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / immunology
  • Choroid / pathology
  • Female
  • Fundus Oculi*
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Melanocytes
  • Middle Aged
  • T-Lymphocytes / immunology
  • T-Lymphocytes, Regulatory / immunology
  • Uveitis / immunology*
  • Uveomeningoencephalitic Syndrome / immunology*
  • Uveomeningoencephalitic Syndrome / pathology


  • Antibodies, Monoclonal