Lack of association between DQ A and DX A polymorphisms with rheumatoid arthritis and Felty's syndrome

Dis Markers. 1990 Mar-Apr;8(2):55-7.

Abstract

DQ A and DX A RFLPs were studied in DR4-positive rheumatoid arthritis, Felty's syndrome, and in DR4-positive control subjects, and in the light of the previously documented association between Felty's syndrome and the DQ B 3.1 allele (3b RFLP). In these DR4-positive subjects there were no preferential associations between DQ A or DX A polymorphisms and rheumatoid arthritis or Felty's syndrome and no evidence for unusual DQ A-B haplotypic associations in Felty's or rheumatoid subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / immunology*
  • Felty Syndrome / immunology*
  • Genetic Variation
  • HLA-D Antigens / genetics*
  • HLA-DQ Antigens / genetics*
  • HLA-DR4 Antigen / analysis
  • Haplotypes
  • Humans
  • Polymorphism, Restriction Fragment Length*

Substances

  • HLA-D Antigens
  • HLA-DQ Antigens
  • HLA-DR4 Antigen
  • HLA-Dx antigen