Accurate assessment of intragenic recombination frequency within the Duchenne muscular dystrophy gene

Genomics. 1990 Aug;7(4):602-6. doi: 10.1016/0888-7543(90)90205-9.


Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy (DMD/BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0.226) over the genomic length of approximately 2 Mb.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genes
  • Genetic Linkage*
  • Humans
  • Introns*
  • Lod Score
  • Muscular Dystrophies / genetics*
  • Polymorphism, Restriction Fragment Length
  • Recombination, Genetic*