Abstract
The nanATEK-yhcH, yjhATS, and yjhBC operons in Escherichia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid in nature. Here we show that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to grow on this alternative sialic acid, which is commonly found in mammalian host mucosal sites.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Escherichia coli / genetics
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Escherichia coli / growth & development*
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Escherichia coli / metabolism*
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / physiology
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Gene Expression Regulation, Bacterial / genetics
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Gene Expression Regulation, Bacterial / physiology
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N-Acetylneuraminic Acid / metabolism
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Sialic Acids / metabolism*
Substances
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Escherichia coli Proteins
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Sialic Acids
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9-O-acetyl-N-acetylneuraminic acid
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N-Acetylneuraminic Acid