Abstract
Synthesis of benzoquinone ansa-adenosines, which are rationally designed as Hsp90 inhibitors by extracting and fusing a natural substrate, ATP, and a natural product, geldanamycin, was described. This simpler scaffold design provides practical synthesis of a set of analogs and demonstrates synthetic innovation.
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine Triphosphate / chemistry
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Benzoquinones / chemical synthesis*
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Benzoquinones / chemistry
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Drug Design
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HSP90 Heat-Shock Proteins / antagonists & inhibitors
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HSP90 Heat-Shock Proteins / chemistry
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Lactams, Macrocyclic / chemistry
Substances
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Antineoplastic Agents
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Benzoquinones
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HSP90 Heat-Shock Proteins
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Lactams, Macrocyclic
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Adenosine Triphosphate
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Adenosine
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geldanamycin