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, 12 (10), 1222-3

Selective Suppression of Hippocampal Ripples Impairs Spatial Memory

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Selective Suppression of Hippocampal Ripples Impairs Spatial Memory

Gabrielle Girardeau et al. Nat Neurosci.

Abstract

Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

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