The status of serum procalcitonin in pulmonary tuberculosis and nontuberculosis pulmonary disease

J Pak Med Assoc. 2009 Sep;59(9):647-8.

Abstract

Procalcitonin (PCT) is a marker of the inflammatory response to infection. In the present study the serum PCT of 46 pulmonary tuberculosis patients, 46 non-tuberculosis pulmonary disease and 46 healthy subjects were analyzed using semiquantitative PCT-Q kit. All healthy individuals (100%) were negative regarding PCT. Using cut-off value of 0.5 ng/ml, The sensitivity, specificity positive predictive value and negative predictive value for serum PCT in distinguishing tuberculous from nontuberculous pulmonary disease were 36.9%, 63.1%, 50% and 50%, respectively. According to our results the serum PCT is not a reliable marker for diagnosis of pulmonary tuberculosis due to low sensitivity and specificity.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Calcitonin / blood*
  • Calcitonin Gene-Related Peptide
  • Case-Control Studies
  • Female
  • Humans
  • Lung Diseases / blood*
  • Male
  • Middle Aged
  • Protein Precursors / blood*
  • Sensitivity and Specificity
  • Tuberculosis, Pulmonary / blood*
  • Young Adult

Substances

  • CALCA protein, human
  • Protein Precursors
  • Calcitonin
  • Calcitonin Gene-Related Peptide