Emerging viral infections of the central nervous system: part 2

Arch Neurol. 2009 Sep;66(9):1065-74. doi: 10.1001/archneurol.2009.189.


The first part of this review ended with a discussion of new niches for known viruses as illustrated by viral central nervous system (CNS) disease associated with organ transplant and the syndrome of human herpesvirus 6-associated posttransplant acute limbic encephalitis. In this part, we begin with a continuation of this theme, reviewing the association of JC virus-associated progressive multifocal leukoencephalopathy (PML) with novel immunomodulatory agents. This part then continues with emerging viral infections associated with importation of infected animals (monkeypox virus), then spread of vectors and enhanced vector competence (chikungunya virus [CHIK]), and novel viruses causing CNS infections including Nipah and Hendra viruses and bat lyssaviruses (BLV).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Central Nervous System Viral Diseases / immunology*
  • Central Nervous System Viral Diseases / physiopathology
  • Central Nervous System Viral Diseases / virology
  • Communicable Diseases, Emerging / immunology*
  • Communicable Diseases, Emerging / physiopathology
  • Communicable Diseases, Emerging / virology
  • Disease Vectors
  • Humans
  • Immunocompromised Host / immunology*
  • Immunosuppressive Agents / adverse effects*
  • Leukoencephalopathy, Progressive Multifocal / immunology*
  • Leukoencephalopathy, Progressive Multifocal / physiopathology
  • Leukoencephalopathy, Progressive Multifocal / virology
  • Virus Physiological Phenomena / immunology
  • Viruses / pathogenicity
  • Zoonoses / transmission*
  • Zoonoses / virology


  • Immunosuppressive Agents