Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 424, 533-43

Allosteric Potentiation of Quisqualate Receptors by a Nootropic Drug Aniracetam

Comparative Study

Allosteric Potentiation of Quisqualate Receptors by a Nootropic Drug Aniracetam

I Ito et al. J Physiol.


1. Allosteric potentiation of the ionotropic quisqualate (iQA) receptor by a nootropic drug aniracetam (1-p-anisoyl-2-pyrrolidinone) was investigated using Xenopus oocytes injected with rat brain mRNA and rat hippocampal slices. 2. Aniracetam potentiates the iQA responses induced in Xenopus oocytes by rat brain mRNA in a reversible manner. This effect was observed above the concentrations of 0.1 mM. Kainate. N-methyl-D-aspartate and gamma-aminobutyric acid responses induced in the same oocytes were not affected. 3. The specific potentiation of iQA responses was accompanied by an increase in the conductance change of iQA and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) responses, but the affinity of receptors for agonist and the ion-selectivity of the channels (reversal potentials) were not changed. 4. Aniracetam reversibly potentiated the iQA responses recorded intracellularly from the pyramidal cells in the CA1 region of rat hippocampal slices. The excitatory postsynaptic potentials (EPSPs) in Schaffer collateral-commissural-CA1 synapses were also potentiated by aniracetam. 5. Population EPSPs recorded in the mossy fibre-CA3 synapses as well as Schaffer-commissural synapses were also potentiated by aniracetam. The amplitudes of the potentiation were not changed by the formation of long-term potentiation.

Similar articles

See all similar articles

Cited by 36 PubMed Central articles

See all "Cited by" articles


    1. Neurosci Lett. 1989 May 22;100(1-3):141-6 - PubMed
    1. Neurosci Lett. 1989 May 8;99(3):333-9 - PubMed
    1. Neuron. 1988 Dec;1(10):911-7 - PubMed
    1. Psychopharmacology (Berl). 1982;78(2):104-11 - PubMed
    1. Nature. 1984 Feb 2-8;307(5950):462-5 - PubMed

Publication types

MeSH terms

LinkOut - more resources