The GRADE system for rating clinical guidelines

PLoS Med. 2009 Sep;6(9):e1000094. doi: 10.1371/journal.pmed.1000094. Epub 2009 Sep 15.


Brian Kavanagh critiques the GRADE system of grading guidelines, arguing that even though it has evolved through the Evidence-Based Medicine movement, there is no evidence that GRADE itself is reliable.

MeSH terms

  • Evidence-Based Medicine / standards*
  • Humans
  • Practice Guidelines as Topic / standards*
  • Respiration, Artificial / standards
  • Respiratory Distress Syndrome / therapy
  • Sepsis / blood
  • Sepsis / drug therapy