Role of Mangifera indica bark polyphenols on rat gastric mucosa against ethanol and cold-restraint stress

Nat Prod Res. 2011 Apr;25(8):815-26. doi: 10.1080/14786410903003822. Epub 2009 Sep 14.

Abstract

This study was carried out in order to investigate the potential and antioxidant effects of polyphenols from Mangifera indica stem bark against gastric damage induced by ethanol and cold-restraint stress. The polyphenols possess good capacity for scavenging nitric oxide (NO) radical and ferric-reducing antioxidant power (FRAP) assay in vitro. Rats were sacrificed after the experiment, and their stomachs were removed for biochemical and histopathological analysis. The severity of lesions was found to markedly decrease by the administration of polyphenols in both models. The increased gastric nitrite level of ethanol administered rats were significantly (p < 0.001) reduced by polyphenol treatment. Administration of polyphenols reduced thiobarbituric acid reactive substance (TBARS) level and increased the GSH level significantly in a dose-dependent manner in both models. Our study revealed the ulcer-protective effects of the polyphenols and could possibly reside for the most part on its anti-radical effects.

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology
  • Cold Temperature
  • Ethanol / toxicity
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology*
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / pathology
  • Glutathione / metabolism
  • Mangifera / chemistry*
  • Phenols / chemistry*
  • Phenols / pharmacology*
  • Plant Bark / chemistry*
  • Polyphenols
  • Ranitidine / pharmacology
  • Rats
  • Rats, Wistar
  • Restraint, Physical / adverse effects*
  • Stomach Diseases / chemically induced
  • Stomach Diseases / etiology
  • Stomach Diseases / prevention & control
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / prevention & control
  • Stress, Physiological / physiology*
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Anti-Ulcer Agents
  • Flavonoids
  • Phenols
  • Polyphenols
  • Thiobarbituric Acid Reactive Substances
  • Ethanol
  • Ranitidine
  • Glutathione