Abstract
Several new 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate (NHQ-DA) have been prepared by chemical modifications of the Diels-Alder adduct of alpha-myrcene and 1,4-benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB-231 breast-adeno carcinoma, A-549 lung carcinoma, and HT-29 colon carcinoma. GI(50) values ranged in and below the micromolar concentration level.
MeSH terms
-
Acetates / chemical synthesis
-
Acetates / pharmacology*
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / pharmacology*
-
Cell Proliferation / drug effects*
-
Cell Survival / drug effects
-
Dose-Response Relationship, Drug
-
HT29 Cells
-
Humans
-
Hydroquinones / chemical synthesis
-
Hydroquinones / pharmacology*
-
Inhibitory Concentration 50
-
Molecular Structure
-
Structure-Activity Relationship
Substances
-
Acetates
-
Antineoplastic Agents
-
Hydroquinones
-
1,4-naphthohydroquinone