Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

Nature. 1990 Sep 13;347(6289):146-51. doi: 10.1038/347146a0.


A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antipsychotic Agents / pharmacology*
  • Base Sequence
  • Brain Chemistry
  • Cell Line
  • Cloning, Molecular*
  • Cricetinae
  • DNA / genetics
  • DNA Restriction Enzymes
  • Dopamine / metabolism
  • Guanylyl Imidodiphosphate / pharmacology
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Polymerase Chain Reaction
  • RNA, Messenger / analysis
  • Rats
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / genetics*
  • Receptors, Dopamine / physiology
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Sequence Homology, Nucleic Acid
  • Tissue Distribution


  • Antipsychotic Agents
  • Drd3 protein, rat
  • RNA, Messenger
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3
  • Guanylyl Imidodiphosphate
  • DNA
  • DNA Restriction Enzymes
  • Dopamine

Associated data

  • GENBANK/X53944