Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

J Nat Prod. 2009 Oct;72(10):1895-8. doi: 10.1021/np900397f.

Abstract

Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells / drug effects
  • Adipogenesis / drug effects*
  • Anemarrhena / chemistry*
  • Animals
  • Coumarins / chemistry
  • Coumarins / isolation & purification*
  • Coumarins / pharmacology*
  • Korea
  • Mice
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Phenols / chemistry
  • Phenols / isolation & purification*
  • Phenols / pharmacology*
  • Plants, Medicinal / chemistry*
  • Rhizome / chemistry

Substances

  • (E)-4'-demethyl-6-methyleucomin
  • Coumarins
  • Phenols
  • anemarchalconyn
  • anemarcoumarin A