Sex differences in a murine model of Sjögren's syndrome

Ann N Y Acad Sci. 2009 Sep;1173:378-83. doi: 10.1111/j.1749-6632.2009.04760.x.

Abstract

Sex differences in a NOD.H2(h4) murine model of Sjögren's syndrome were analyzed. Compared to males, female NOD.H2(h4) mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4(+) T cells in salivary gland infiltrates. CD4(+) T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.

MeSH terms

  • Animals
  • CD11b Antigen / metabolism
  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / pathology
  • Cytokines / metabolism*
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Interleukin-10 / metabolism
  • Interleukin-17 / metabolism
  • Interleukin-2 / metabolism
  • Interleukin-4 / metabolism
  • Interleukin-9 / metabolism
  • Leukocyte Common Antigens / metabolism
  • Macrophages / metabolism
  • Macrophages / pathology
  • Male
  • Mice
  • Mice, Congenic
  • Mice, Inbred NOD
  • Salivary Glands / metabolism
  • Salivary Glands / pathology
  • Sex Factors
  • Sialadenitis / metabolism
  • Sialadenitis / pathology
  • Sjogren's Syndrome / metabolism*
  • Sjogren's Syndrome / pathology*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • CD11b Antigen
  • Cytokines
  • Interleukin-17
  • Interleukin-2
  • Interleukin-9
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Interleukin-4
  • Leukocyte Common Antigens