Abstract
Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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APOBEC-3G Deaminase
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Antigens, CD / physiology
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Antiviral Restriction Factors
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Carrier Proteins / physiology
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Cyclophilin A / physiology
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Cytidine Deaminase / physiology
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GPI-Linked Proteins
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HIV Infections / immunology*
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HIV Infections / virology
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HIV-1 / immunology*
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Humans
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Immunity, Innate*
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Membrane Glycoproteins / physiology
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MicroRNAs / physiology
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Tripartite Motif Proteins
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Ubiquitin-Protein Ligases
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Virus Replication / immunology*
Substances
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Antigens, CD
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Antiviral Restriction Factors
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BST2 protein, human
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Carrier Proteins
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GPI-Linked Proteins
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Membrane Glycoproteins
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MicroRNAs
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Tripartite Motif Proteins
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TRIM5 protein, human
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Ubiquitin-Protein Ligases
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APOBEC-3G Deaminase
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APOBEC3G protein, human
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Cytidine Deaminase
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Cyclophilin A