Coronary sinus stent implantation improves acute ischaemic mitral valve regurgitation; an experimental safety and efficacy study

EuroIntervention. 2007 Aug;3(2):280-5. doi: 10.4244/eijv3i2a48.


Aims: Percutaneous implantation of a large stent was performed in the coronary sinus of pigs, to assess safety and immediate efficacy for reduction of acute ischaemic mitral regurgitation.

Methods and results: Acute ischaemic mitral regurgitation (MR) was produced in seven pigs, continuously monitored with echocardiography, during repeated balloon inflations in the proximal left circumflex artery. The protocol was repeated following placement of a stent in the coronary sinus. Five pigs survived the period of acute ischaemia and developed severe mitral regurgitation (>/=3+/4+). Following successful stent implantation, the MR area decreased from 2.4+/-0.4 cm2 to 1.1+/-0.6 cm2 (p=0.016) and the proximal isovelocity surface area (PISA) MR flow from 63.9+/-37.3 ml/sec to 44.0+/-35.0 ml/sec (p=0.029). Coronary sinus stent prevented the ischaemia-induced increase in septal-lateral mitral annulus dimension (p=0.041) and left ventricular dilatation. Three animals were allowed to recover and underwent histological analysis of the coronary sinus stent at 30 days, showing endothelialisation and minimal hyperplasia, without thrombus formation.

Conclusions: A percutaneously deployed stent in the coronary sinus may help to decrease the severity of acute ischaemic mitral regurgitation.