p53 and metabolism

Nat Rev Cancer. 2009 Oct;9(10):691-700. doi: 10.1038/nrc2715. Epub 2009 Sep 17.


Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autophagy
  • Cell Proliferation
  • Cell Transformation, Neoplastic / metabolism*
  • Glycolysis
  • Humans
  • Neoplasms / metabolism*
  • Oxidative Stress
  • Tumor Suppressor Protein p53 / metabolism*


  • Tumor Suppressor Protein p53