Hemosorption and endolymphatic pharmacotherapy was included in the complex of treatment in 65 patients operated upon for spreaded forms of peritonitis and acute ileus. Hemosorption was performed within 12-24 h after operation, pharmacological agents (Aceclidine++, Cerucal, Obsidan) were introduced by antegrade endolymphatic infusions 4-6 h after hemosorption. The investigations have shown that in this case there rapidly appears intestinal peristalsis which is maintained not less than for 10-12 hours and in great part of patients it was completely recovered. Multiple stimulations by traditional methods were necessary in the control group to restore peristalsis. The combination of hemosorption and endolymphatic therapy may be recommended as an effective complex for the struggle against intestinal paresis in peritonitis and acute ileus in the postoperative period.