Sellar collision tumor involving pituitary gonadotroph adenoma and chondroma: a potential clinical diagnosis

Pituitary. 2011 Dec;14(4):405-8. doi: 10.1007/s11102-009-0199-6. Epub 2009 Sep 17.


We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with a pituitary adenoma. A transseptal transsphenoidal tumor mass reduction yielded a histological diagnosis of a collision tumor comprised of a gonadotroph adenoma intermingled with osteochondroma. We discuss a potential causal relationship between the administration of the long-acting gonadotropin-releasing hormone agonist and the sudden appearance of the previously unsuspected sellar lesion. Although the association of these two tumors is very likely coincidental, the possibility of causal relationship is addressed.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / chemically induced
  • Adenoma / diagnosis*
  • Adenoma / pathology
  • Aged
  • Antineoplastic Agents, Hormonal / adverse effects
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Chondroma / chemically induced
  • Chondroma / diagnosis*
  • Chondroma / pathology
  • Diagnostic Techniques, Endocrine
  • Gonadotrophs / pathology*
  • Gonadotropin-Releasing Hormone / adverse effects
  • Gonadotropin-Releasing Hormone / analogs & derivatives
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Humans
  • Male
  • Mixed Tumor, Malignant / chemically induced
  • Mixed Tumor, Malignant / diagnosis*
  • Mixed Tumor, Malignant / pathology
  • Neoplasms, Second Primary / chemically induced
  • Neoplasms, Second Primary / diagnosis
  • Pituitary Neoplasms / chemically induced
  • Pituitary Neoplasms / diagnosis*
  • Pituitary Neoplasms / pathology
  • Prostatic Neoplasms / drug therapy
  • Sella Turcica / pathology*
  • Stress, Mechanical


  • Antineoplastic Agents, Hormonal
  • Gonadotropin-Releasing Hormone