Jejunal Efflux in Short Bowel Syndrome

Lancet. 1990 Sep 29;336(8718):765-8. doi: 10.1016/0140-6736(90)93238-k.

Abstract

24 h oral intake and intestinal output were studied in 15 patients with a short residual length of jejunum and no colon. 8 patients showed a net secretory, and 7 a net absorptive response to food. In secretors, daily intestinal output exceeded oral intake (mean 2.3 kg wet weight, and 233 mmol sodium). Long-term parenteral fluid and electrolyte replacements were needed only in those with a secretory response. Jejunal length inversely correlated with net intestinal output of fluid, sodium, potassium, and with percentage energy absorption. A secretory response was observed if jejunal length was less than 100 cm and was reduced by gastric antisecretory drugs and octreotide.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adult
  • Female
  • Food*
  • Humans
  • Injections, Intravenous
  • Intestinal Absorption / drug effects
  • Jejunostomy
  • Jejunum / drug effects
  • Jejunum / metabolism*
  • Jejunum / pathology
  • Malabsorption Syndromes / metabolism*
  • Male
  • Middle Aged
  • Octreotide / pharmacology
  • Omeprazole / pharmacology
  • Parenteral Nutrition
  • Potassium / metabolism*
  • Ranitidine / pharmacology
  • Short Bowel Syndrome / metabolism*
  • Short Bowel Syndrome / pathology
  • Short Bowel Syndrome / therapy
  • Sodium / metabolism*

Substances

  • Ranitidine
  • Sodium
  • Omeprazole
  • Octreotide
  • Potassium