Age, tumor size, type of surgery, and gender predict survival in early stage (stage I and II) non-small cell lung cancer after surgical resection

Lung Cancer. 2010 Jun;68(3):398-402. doi: 10.1016/j.lungcan.2009.08.008. Epub 2009 Sep 16.


Background: Even after presumably curative resection the 5-year survival rates are only 60-80% in stage I and 40-50% in stage II NSCLC. Purpose of the present study was the identification of independent clinico-pathological predictors of their survival.

Methods: A retrospective review of 519 consecutive subjects who had undergone attempted curative resection for stage I or II NSCLC was performed. Patients who had received any adjuvant or neo-adjuvant chemo- or radiation therapy were excluded. Primary outcome measure was the duration of overall survival.

Results: Median survival was 7.25 years for stage IA, 5.71 years for stage IB and 3.85 years for stage IIB. In univariate analysis, six variables were significantly associated (p-value<0.05) with poorer survival: older age, larger size of the tumor, male gender, surgery other than lobectomy, squamous histology and later stages (stage IB and IIB). In multivariate analysis, age (Hazard ratio=1.06 per year increase in age; p<0.0001), larger tumor size (Hazard ratio=1.54 per doubling of tumor size; p<0.0001), type of surgery (Hazard ratio=1.50 for surgery other than lobectomy; p=0.036), and gender (Hazard ratio=1.45 for male gender; p=0.039) were the predictors of overall survival.

Conclusions: In surgically treated early stage (I and II) NSCLC patients, age, tumor size, type of surgery, and gender are the important predictors of survival.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / physiopathology*
  • Carcinoma, Non-Small-Cell Lung / surgery*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms / mortality
  • Lung Neoplasms / physiopathology*
  • Lung Neoplasms / surgery*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Sex Factors
  • Survival Analysis
  • Thoracic Surgical Procedures*
  • Tumor Burden