Role of Somatostatin and Its Analogues in the Pathogenesis and Treatment of Diabetes Mellitus

Metabolism. 1990 Sep;39(9 Suppl 2):52-4. doi: 10.1016/0026-0495(90)90211-t.


Somatostatin secreted by pancreatic D cells is a potent inhibitor of insulin, glucagon and growth hormone secretion, as well as other cells. The role of abnormal pancreatic D-cell function in diabetes mellitus is unclear. However, development of long-acting selective somatostatin analogs might prove useful in the treatment of diabetes.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / etiology*
  • Humans
  • Islets of Langerhans / metabolism
  • Somatostatin / physiology*
  • Somatostatin / therapeutic use


  • Somatostatin