A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy

Anesth Analg. 2009 Oct;109(4):1279-83. doi: 10.1213/ane.0b013e3181b0f0bb.

Abstract

Introduction: In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.

Methods: Ninety-one women received IV oxycodone or morphine before the end of laparoscopic hysterectomy and then continued with patient-controlled analgesia for 24 h postoperatively.

Results: The accumulated oxycodone consumption was less (13.3 +/- 10.4 mg vs 22.0 +/- 13.1 mg, P = 0.001) than morphine. With oxycodone, the visual analog scale scores were significantly lower in the first hour postoperatively and sedation was less during the 24-h postoperative period, P = 0.006.

Conclusions: Oxycodone was more potent than morphine for visceral pain relief but not for sedation.

Trial registration: ClinicalTrials.gov NCT00528177.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analgesia, Patient-Controlled*
  • Analgesics, Opioid / administration & dosage*
  • Analgesics, Opioid / adverse effects
  • Double-Blind Method
  • Female
  • Humans
  • Hysterectomy*
  • Injections, Intravenous
  • Laparoscopy*
  • Middle Aged
  • Morphine / administration & dosage*
  • Morphine / adverse effects
  • Oxycodone / administration & dosage*
  • Oxycodone / adverse effects
  • Pain Measurement
  • Pain, Postoperative / prevention & control*
  • Sleep / drug effects
  • Time Factors

Substances

  • Analgesics, Opioid
  • Morphine
  • Oxycodone

Associated data

  • ClinicalTrials.gov/NCT00528177