Modeling spatial and temporal dynamics of chemotactic networks

Methods Mol Biol. 2009:571:489-505. doi: 10.1007/978-1-60761-198-1_32.


When stimulated by chemoattractants, eukaryotic cells respond through a combination of temporal and spatial dynamics. These responses come about because of the interaction of a large number of signaling components. The complexity of these systems makes it hard to understand without a means of systematically generating and testing hypotheses. Computer simulations have proved to be useful in testing conceptual models. Here we outline the steps required to develop these models.

MeSH terms

  • Chemotaxis / physiology*
  • Models, Theoretical*
  • Signal Transduction