Changes in IGF-I, IGFBP-3 and ghrelin levels after adenotonsillectomy in children with sleep disordered breathing

Int J Pediatr Otorhinolaryngol. 2009 Dec;73(12):1653-6. doi: 10.1016/j.ijporl.2009.08.025. Epub 2009 Sep 18.


Objective: The aim of this study was to determine the changes in insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and ghrelin levels following adenotonsillectomy (T&A) in children with sleep disordered breathing (SDB).

Methods: Forty children (mean age 4.85+/-2.15 years) clinically diagnosed with adenotonsillar hypertrophy (ATH) related SDB were enrolled. All children underwent T&A. Serum levels of IGF-I, IGFBP-3 and ghrelin were measured before and 6 months after T&A.

Results: Serum levels of IGF-I and IGFBP-3 were significantly higher after T&A (p<0.001). Serum ghrelin levels showed a significant decrease after T&A (p<0.001).

Conclusion: Children with ATH related SDB who underwent T&A showed significant increases in IGF-I and IGFBP-3 levels indicating an increase in diurnal growth hormone secretion as well as a significant decrese in ghrelin levels indicating an increased oral food intake in the postoperative period.

MeSH terms

  • Adenoidectomy / methods*
  • Adenoids / pathology
  • Adenoids / surgery
  • Biomarkers / blood
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Ghrelin / blood*
  • Humans
  • Hypertrophy / pathology
  • Hypertrophy / surgery
  • Insulin-Like Growth Factor Binding Protein 3 / blood*
  • Insulin-Like Growth Factor I / metabolism*
  • Male
  • Palatine Tonsil / pathology
  • Palatine Tonsil / surgery
  • Postoperative Care
  • Preoperative Care
  • Prospective Studies
  • Sleep Apnea Syndromes / blood*
  • Sleep Apnea Syndromes / etiology*
  • Sleep Apnea Syndromes / surgery
  • Tonsillectomy / methods*
  • Treatment Outcome


  • Biomarkers
  • Ghrelin
  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor I