The Helicobacter pylori Mfd protein is important for antibiotic resistance and DNA repair

Diagn Microbiol Infect Dis. 2009 Dec;65(4):454-6. doi: 10.1016/j.diagmicrobio.2009.08.007. Epub 2009 Sep 18.

Abstract

A Helicobacter pylori mutant defective in a putative mfd gene was constructed and characterized. The mfd gene is required for DNA repair and is involved in DNA recombination processes. The mfd mutant strain displayed a greatly increased susceptibility to antibiotics, indicating that this gene plays a significant role in the antibiotic resistance of H. pylori strain J99.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / physiology*
  • Colony Count, Microbial
  • DNA Repair*
  • Drug Resistance, Bacterial*
  • Gene Deletion
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / physiology*
  • Microbial Sensitivity Tests
  • Mitomycin / pharmacology
  • Recombination, Genetic
  • Transcription Factors / deficiency
  • Transcription Factors / physiology*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Transcription Factors
  • transcription repair coupling factor protein, Bacteria
  • Mitomycin