Beta-lactamase-negative, methicillin-resistant Staphylococcus aureus in a newborn nursery: report of an outbreak and laboratory investigations

J Hosp Infect. 1990 Aug;16(2):109-21. doi: 10.1016/0195-6701(90)90055-s.


An outbreak of skin infection caused by a beta-lactamase-negative strain of methicillin-resistant Staphylococcus aureus (MRSA) occurred during a five-week period in a newborn nursery. Twelve babies, two mothers and two members of staff were involved. One baby had a diagnosis of staphylococcal scalded skin syndrome and two others required treatment with antibiotics. The infecting strain produced exfoliative toxin A. It was thought that it had been introduced from a different maternity unit by a nasal carrier. Laboratory investigations tended to support this hypothesis.

MeSH terms

  • Bacteriophage Typing
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Cross Infection / prevention & control
  • Disease Outbreaks*
  • Exfoliatins / biosynthesis
  • Humans
  • Infant, Newborn
  • Methicillin Resistance
  • Nurseries, Hospital*
  • Plasmids
  • Restriction Mapping
  • Staphylococcal Skin Infections / epidemiology*
  • Staphylococcal Skin Infections / microbiology
  • Staphylococcal Skin Infections / prevention & control
  • Staphylococcus aureus / classification
  • Staphylococcus aureus / genetics
  • Wales / epidemiology


  • Exfoliatins