Synaptic Plasticity in the Subiculum

Prog Neurobiol. 2009 Dec;89(4):334-42. doi: 10.1016/j.pneurobio.2009.09.002. Epub 2009 Sep 19.

Abstract

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Cerebral Cortex / physiology
  • Hippocampus / cytology*
  • Hippocampus / physiology*
  • Humans
  • Learning / physiology
  • Models, Biological
  • Neural Pathways / anatomy & histology
  • Neural Pathways / physiology
  • Neuronal Plasticity / physiology*
  • Pyramidal Cells / physiology*
  • Signal Transduction / physiology
  • Synapses / physiology*