A complex clinical-instrumental study included 138 patients with discirculatory encephalopathy (DE) who received cavinton perorally in dose 30 mg/day during 90 days (2 courses in a year) in addition to the basic therapy (hypotensive and antithrombotic drugs, neuroprotector glycine). A control group comprised 98 patients clinically matched with the main group. They received only basic therapy. Neurological status and results of neuropsychological tests were assessed before treatment and to the end of 3, 6 and 12 months. The improvement of all neurological syndromes studied was seen in the main group to the end of 12 months as compared to controls. The complex treatment using cavinton led to the significant decrease of risk of DE progression, development of transitory ischemic attacks and strokes compared to controls (relative risks were 0,01 and 0,14, respectively).