doi: 10.1038/347477a0.
Two components of long-term potentiation induced by different patterns of afferent activation
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- PMID: 1977084
- DOI: 10.1038/347477a0
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Two components of long-term potentiation induced by different patterns of afferent activation
Nature.
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Abstract
Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.
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