Neuromuscular diseases associated with HIV-1 infection

Muscle Nerve. 2009 Dec;40(6):1043-53. doi: 10.1002/mus.21465.


Neuromuscular disorders are common in human immunodeficiency virus (HIV); they occur at all stages of disease and affect all parts of the peripheral nervous system. These disorders have diverse etiologies including HIV itself, immune suppression and dysregulation, comorbid illnesses and infections, and side effects of medications. In this article, we review the following HIV-associated conditions: distal symmetric polyneuropathy; inflammatory demyelinating polyneuropathy; mononeuropathy; mononeuropathy multiplex; autonomic neuropathy; progressive polyradiculopathy due to cytomegalovirus; herpes zoster; myopathy; and other, rarer disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • HIV Infections / complications*
  • HIV-1*
  • Humans
  • Polyneuropathies / pathology
  • Polyneuropathies / physiopathology*
  • Polyneuropathies / virology*
  • Quality of Life