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. 2009 Dec;48(3):290-4.
doi: 10.1016/j.cyto.2009.08.011. Epub 2009 Sep 20.

Increased Circulating IL-8 Is Associated With Reduced IGF-1 and Related to Poor Metabolic Control in Adolescents With Type 1 Diabetes Mellitus

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Increased Circulating IL-8 Is Associated With Reduced IGF-1 and Related to Poor Metabolic Control in Adolescents With Type 1 Diabetes Mellitus

Bradley J Van Sickle et al. Cytokine. .
Free PMC article

Abstract

Background: A dysregulated growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis is well-recognized in children and adolescents with type 1 diabetes mellitus (T1DM). Decreased IGF-1 levels can also be found in chronic inflammatory diseases, while hyperglycemia promotes inflammatory cytokine production. Therefore, inflammatory cytokines may link poor metabolic control with GH/IGF-1 axis changes. This study examined the relationship between serum inflammatory cytokines and IGF-1 in adolescents (age 13-18) with TIDM in chronic poor (n=17) or favorable (n=19) glucose control. Poor control (PC) was defined as >or=3, consistent HbA1C>9% during the previous 2 years, while favorable control (FC) was consistent levels of HbA1C<9%.

Results: HbA1C (FC: 7.5+/-0.6%; PC: 10.5+/-0.9%, p<0.001) and interleukin (IL)-8 (FC: 3.7+/-4.0 pg/ml; PC: 7.4+/-4.3 pg/ml, p=0.01) were increased and IGF-1 (FC: 536.5+/-164.3 ng/ml; PC: 408.9+/-157.1 ng/ml, p=0.03) was decreased in patients with poor control compared to patients with favorable control. Moreover, IL-8 was inversely correlated with IGF-1 (r=-0.40, p=0.03) and positively correlated with HbA1C (r=0.36, p=0.03).

Conclusions: In adolescents with T1DM and chronic, poor glucose control, increased serum IL-8 is associated with reduced IGF-1 suggesting a pro-inflammatory milieu that may contribute to alterations in the GH/IGF-1 axis.

Figures

Fig. 1
Fig. 1
Comparison of serum IL-8 levels in adolescents with TIDM in favorable or poor metabolic control.
Fig. 2
Fig. 2
Relationships among HbA1C, IGF-1 and IL-8 in adolescents with T1DM.

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