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Comparative Study
, 54 (3), 191-7

Isolation of a cDNA Probe for the Human Intestinal Dipeptidylpeptidase IV and Assignment of the Gene Locus DPP4 to Chromosome 2

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Comparative Study

Isolation of a cDNA Probe for the Human Intestinal Dipeptidylpeptidase IV and Assignment of the Gene Locus DPP4 to Chromosome 2

D Darmoul et al. Ann Hum Genet.

Abstract

We report the nucleotide sequence and derived amino-acid sequence of a cDNA clone encoding the 3' end of human intestinal dipeptidylpeptidase IV (DPP-IV). This cDNA probe identifies a 4 kb mRNA in the human colon cancer cell line Caco-2. We demonstrate here an extensive homology between this human DPP-IV cDNA and the recently published rat liver DPP-IV cDNA. Using the human DPP-IV cDNA to probe genomic DNA from a panel of somatic cell hybrids we have assigned the gene encoding human DPP-IV to chromosome 2.

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