Effect of closed endotracheal suction in high-frequency ventilated premature infants measured with electrical impedance tomography

Intensive Care Med. 2009 Dec;35(12):2130-4. doi: 10.1007/s00134-009-1663-5. Epub 2009 Sep 23.


Objective: To determine the global and regional changes in lung volume during and after closed endotracheal tube (ETT) suction in high-frequency ventilated preterm infants with respiratory distress syndrome (RDS).

Design: Prospective observational clinical study.

Setting: Neonatal intensive care unit.

Patients: Eleven non-muscle relaxed preterm infants with RDS ventilated with open lung high-frequency ventilation (HFV).

Interventions: Closed ETT suction.

Measurements and results: Changes in global and regional lung volume were measured with electrical impedance tomography. ETT suction resulted in an acute loss of lung volume followed by spontaneous recovery with a median residual loss of 3.3% of the maximum volume loss. The median stabilization time was 8 s. At the regional level, the lung volume changes during and after ETT suction were heterogeneous in nature.

Conclusions: Closed ETT suction causes an acute, transient and heterogeneous loss of lung volume in premature infants with RDS treated with open lung HFV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electric Impedance
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Intensive Care Units, Neonatal
  • Intubation, Intratracheal*
  • Lung Compliance
  • Lung Volume Measurements
  • Prospective Studies
  • Respiratory Insufficiency / diagnosis
  • Respiratory Insufficiency / therapy*
  • Suction / methods*
  • Tomography*